Though the Miscellaneous Manuscripts collection is composed of items that do not fall readily into any other existing collection, the two dominant intellectual areas represented in the collection are Early American History and History of Science.

The Anthony F. C. Wallace Papers include correspondence to and from 20th century anthropologists, ethnologists, historians, linguists, and psychiatrists and provides a wealth of resources for the study of technological and social change, American Indians, culture and personality, revitalization movements, the anthropological study of religion, and the cultural and biological bases of behavior. In addition to Wallace's correspondence, research notes, and drafts, the collection includes Wallace family correspondence and photographs, as well as Wallace's writings from childhood through recent years.